Creamy Cajun Shrimp Pasta Bake

There’s something irresistibly comforting about a pasta bake loaded with succulent shrimp, a creamy sauce, and a kick of Cajun spice. This Creamy Cajun Shrimp Pasta Bake blends tender penne pasta with juicy shrimp, vibrant bell peppers, and a luscious cheesy sauce that bakes into bubbly perfection. Whether it’s a weeknight dinner or a special occasion, this dish promises rich flavor and satisfying textures that will keep you coming back for more. It’s a one-pan wonder that’s both elegant and easy to make, perfect for when you want something indulgent without the fuss.

Why It Works Every Time

There’s a magic in combining simple ingredients like pasta, shrimp, and cheese with bold Cajun seasoning. The seasoning adds just the right amount of smoky heat without overpowering the delicate shrimp. Using penne pasta is ideal because its tube shape traps the creamy sauce, ensuring every bite is flavorful. Plus, baking the pasta melds the flavors and creates a golden, bubbly cheese crust on top. The mixture of Parmesan and mozzarella offers a perfect balance — Parmesan for sharp, nutty notes, and mozzarella for gooey meltiness. Lastly, finishing with fresh parsley adds a fresh herbal contrast that brightens the dish. This recipe is foolproof because it balances textures and flavors while being straightforward to prepare.

Ingredient Checklist

• 8 ounces penne pasta
• 1 pound shrimp, deveined and peeled
• 2 tablespoons olive oil
• 1 medium onion, diced
• 3 cloves garlic, minced
• 1 bell pepper, diced (any color works)
• 1 teaspoon Cajun seasoning
• 1 cup heavy cream
• 1 cup grated Parmesan cheese
• 1 cup shredded mozzarella cheese
• Salt and pepper to taste
• 2 tablespoons fresh parsley, chopped

Must-Have Equipment

• Large pot – for boiling the pasta
• Large skillet or sauté pan – to cook the shrimp and vegetables
• Baking dish (9×13 inches works well) – for assembling and baking the pasta
• Mixing spoon or spatula – to stir ingredients together
• Cheese grater – if grating fresh Parmesan

Creamy Cajun Shrimp Pasta Bake — Do This Next

Step 1: Preheat and Prep

Preheat your oven to 375°F (190°C). Bring a large pot of salted water to a boil and cook the penne pasta according to package instructions until al dente. Drain and set aside.

Step 2: Sauté Aromatics and Vegetables

In a large skillet, heat the olive oil over medium heat. Add the diced onion and sauté until translucent, about 3-4 minutes. Add the minced garlic and diced bell pepper, cooking for another 2-3 minutes until fragrant and softened.

Step 3: Cook the Shrimp

Toss the peeled and deveined shrimp with the Cajun seasoning, salt, and pepper. Add the shrimp to the skillet and cook for 2-3 minutes on each side until pink and opaque. Remove the skillet from heat once cooked.

Step 4: Make the Creamy Sauce

Pour the heavy cream into the skillet with the shrimp and vegetables. Stir in the grated Parmesan cheese until melted and combined into a creamy sauce. Adjust seasoning with salt and pepper as needed.

Step 5: Combine Pasta and Sauce

Add the cooked penne pasta to the skillet and toss gently to coat all the pasta with the creamy Cajun sauce and shrimp mixture.

Step 6: Assemble and Bake

Transfer the pasta mixture to a greased baking dish. Sprinkle the shredded mozzarella evenly over the top. Bake in the preheated oven for 15-20 minutes, until the cheese is melted, bubbly, and golden brown on top.

Step 7: Garnish and Serve

Remove from the oven and sprinkle with freshly chopped parsley for a pop of color and fresh flavor. Serve warm and enjoy!

Ingredient Flex Options

• Swap penne pasta for rigatoni, fusilli, or rotini for a similar texture.
• Use coconut cream instead of heavy cream for a dairy-free version with a hint of sweetness.
• Add diced tomatoes or sun-dried tomatoes to the sauce for extra tang and color.
• Substitute the bell pepper with diced zucchini or mushrooms for variety.
• Use smoked paprika or chipotle powder if you want a smoky twist on the Cajun seasoning.
• Top with a sprinkle of crushed red pepper flakes for additional heat.

Avoid These Mistakes

• Overcooking the shrimp — shrimp cook quickly and become rubbery if overdone. Remove from heat promptly once pink and firm.
• Under-seasoning the sauce — Cajun seasoning should be balanced with salt and pepper; taste before baking.
• Skipping the pasta’s al dente stage — overcooked pasta will become mushy after baking.
• Not greasing the baking dish — to prevent sticking and make serving easier.
• Using pre-shredded cheese with additives — fresh cheese melts better and creates a creamier texture.

Prep Ahead & Store

You can prepare the entire pasta and shrimp mixture a day in advance and keep it covered in the refrigerator. When ready to serve, sprinkle the mozzarella cheese on top and bake as directed. This makes it a great make-ahead meal for busy evenings.

Leftovers store well in an airtight container in the fridge for up to 3 days. Reheat gently in the oven or microwave to preserve the creamy texture and cheesy goodness.

Ask & Learn

Can I use frozen shrimp for this recipe?

Yes! Just be sure to thaw frozen shrimp completely before cooking. Pat them dry to remove excess moisture, which helps achieve a better sear and prevents the sauce from becoming watery.

What can I substitute for heavy cream?

You can use half-and-half or a combination of milk and cream cheese for a lighter sauce, though it won’t be quite as rich. For a dairy-free option, canned coconut milk or cream works well and adds a subtle sweetness.

Is this recipe spicy?

The Cajun seasoning adds a mild to moderate heat depending on the brand and amount used. You can adjust the spice level by adding more or less seasoning or balancing it with extra cream and cheese if you prefer a milder dish.

How do I make this dish gluten-free?

Simply swap the penne pasta for a gluten-free pasta variety. Many brands offer corn, rice, or chickpea-based pasta that works perfectly in this bake.

Next Up in Your Queue

• Love shrimp and cream sauces? Try the Creamy Cajun Shrimp Alfredo Pasta for a luscious twist.
• Looking for a tomato-based seafood pasta? The Creamy Tomato Basil Shrimp Pasta is a fresh favorite.
• For a lighter, garlic-infused pasta, check out the Shrimp Scampi With Pasta Recipe.

Bring It to the Table

This Creamy Cajun Shrimp Pasta Bake pairs beautifully with a crisp green salad and crusty bread to soak up every last bit of the sauce. A squeeze of fresh lemon on the side can brighten the flavors even further. Whether you’re serving it for family dinner or entertaining guests, it’s a dish that feels both special and approachable. The warm, cheesy top and the spicy, creamy filling beneath create a wonderful contrast that’s sure to become a regular in your recipe rotation.

This dish is a celebration of bold Cajun flavors combined with creamy indulgence, all baked to perfection. So grab your skillet, your favorite pasta, and dive into this deliciously satisfying meal tonight!

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