Creamy Tuscan Chicken Pasta Bake

If you’re craving a comforting, cheesy, and flavorful dish that combines tender chicken, fresh vegetables, and pasta all baked to perfection, this Creamy Tuscan Chicken Pasta Bake is your new go-to meal. With a luscious blend of cream, Parmesan, and mozzarella cheeses, plus the vibrant taste of spinach and cherry tomatoes, this dish brings the warmth and richness of Tuscan flavors right into your kitchen. It’s an effortless crowd-pleaser that satisfies on all levels—perfect for weeknight dinners or special occasions.

Why It Works Every Time

The magic behind this Creamy Tuscan Chicken Pasta Bake lies in its perfect balance of textures and flavors. The penne pasta holds up beautifully in the creamy sauce without getting mushy, while the diced chicken stays juicy and tender thanks to a quick sauté with garlic and onion powders. Fresh spinach and cherry tomatoes add brightness and a pop of color, keeping the dish from feeling too heavy. The combination of Parmesan and mozzarella cheeses melted on top creates a golden, bubbly crust that makes every bite irresistible.

Plus, the Italian seasoning infuses the dish with aromatic herbs that elevate each mouthful. This dish is not only delicious but also incredibly versatile and easy to customize, making it a reliable favorite for any weeknight.

What You’ll Gather

• 2 cups penne pasta – the perfect pasta shape to hold the creamy sauce
• 2 tablespoons olive oil – for sautéing the chicken
• 1 pound boneless, skinless chicken breasts, diced – tender protein to keep the dish hearty
• 1 teaspoon garlic powder – adds depth of flavor
• 1 teaspoon onion powder – complements the garlic perfectly
• Salt and pepper to taste – essential seasoning
• 1 cup cherry tomatoes, halved – bursts of sweetness and acidity
• 2 cups fresh spinach – adds freshness and color
• 1 cup heavy cream – creates the rich, creamy base
• 1 cup grated Parmesan cheese – sharp and nutty flavor
• 1 cup mozzarella cheese, shredded – melty and gooey topping
• 1 teaspoon Italian seasoning – blend of herbs including oregano, basil, and thyme

Recommended Tools

• Large pot – to boil the pasta
• Skillet or sauté pan – for cooking the chicken and veggies
• Baking dish (9×13 inch) – to bake the assembled pasta bake
• Mixing spoon or spatula – for combining ingredients
• Measuring cups and spoons – to ensure accurate ingredient amounts
• Cheese grater – for fresh Parmesan and shredding mozzarella

Method: Creamy Tuscan Chicken Pasta Bake

Step 1: Prepare the Pasta

Bring a large pot of salted water to a boil. Add the penne pasta and cook according to package instructions until al dente (usually about 9-11 minutes). Drain the pasta and set aside.

Step 2: Cook the Chicken

Heat olive oil in a large skillet over medium-high heat. Add the diced chicken breasts, then season with garlic powder, onion powder, salt, and pepper. Cook for 5-7 minutes, stirring occasionally, until the chicken is cooked through and lightly golden.

Step 3: Add Vegetables

Stir in the halved cherry tomatoes and fresh spinach to the skillet with the chicken. Cook for another 2-3 minutes until the spinach wilts and the tomatoes soften slightly.

Step 4: Make the Creamy Sauce

Lower the heat to medium. Pour the heavy cream into the skillet, then sprinkle in the Italian seasoning and half of the Parmesan cheese. Stir everything together until the cheese melts and the sauce thickens slightly.

Step 5: Combine Pasta and Sauce

Add the cooked penne pasta to the skillet and gently toss to coat the pasta evenly with the creamy sauce, chicken, and vegetables.

Step 6: Assemble and Bake

Transfer the pasta mixture into a greased baking dish. Sprinkle the shredded mozzarella and remaining Parmesan cheese evenly over the top. Bake in a preheated oven at 375°F (190°C) for 20-25 minutes, or until the cheese is bubbling and golden brown.

Step 7: Serve and Enjoy

Allow the bake to cool for a few minutes before serving. This dish pairs beautifully with a crisp green salad or garlic bread for a complete meal.

Spring–Summer–Fall–Winter Ideas

• Spring: Add fresh asparagus tips or peas to brighten up the dish.
• Summer: Substitute cherry tomatoes with sun-dried tomatoes for an intense flavor; try the Creamy Sun Dried Tomato Chicken Penne for inspiration.
• Fall: Incorporate roasted butternut squash or mushrooms for earthiness.
• Winter: Stir in some roasted red peppers and swap fresh spinach for kale to add heartiness.

Behind-the-Scenes Notes

• Choosing the right pasta is key: penne holds sauce exceptionally well and withstands baking without becoming mushy.
• Using diced chicken breasts ensures quick cooking and even distribution throughout the dish.
• For an extra flavor boost, you can sauté minced garlic fresh instead of using garlic powder.
• Shredding your own mozzarella and grating Parmesan fresh will always yield better melting and richer taste.
• Don’t skip letting the bake rest post-oven; this helps the sauce set and makes serving cleaner.
• For a lighter option, you can substitute heavy cream for half-and-half, but expect a slightly thinner sauce.

Cooling, Storing & Rewarming

After baking, let the Creamy Tuscan Chicken Pasta Bake cool to room temperature. Store leftovers in an airtight container in the refrigerator for up to 3 days. When reheating, warm individual portions in the microwave or in an oven-safe dish at 350°F (175°C) until heated through, about 15-20 minutes. You may want to add a splash of cream or milk when reheating to restore creaminess if it thickens too much. This dish also freezes well—wrap it tightly and freeze for up to 2 months. Thaw overnight in the fridge before reheating.

Ask & Learn

Can I use chicken thighs instead of breasts?

Absolutely! Chicken thighs add extra juiciness and flavor. Just dice them similarly and follow the same cooking time, though they may take a minute or two longer to cook through.

Is it possible to make this dish dairy-free?

Yes, you can substitute the heavy cream and cheeses with plant-based alternatives like coconut cream and dairy-free mozzarella and Parmesan-style nutritional yeast blends. The texture and flavor will differ slightly but remain delicious.

Can I prepare this ahead of time?

Yes, you can assemble the pasta bake the day before and keep it covered in the fridge. When ready to serve, bake it as directed, adding a few extra minutes if baking straight from the refrigerator.

What can I serve alongside this pasta bake?

A fresh green salad with a tangy vinaigrette, garlic bread, or steamed vegetables complement the rich Creamy Tuscan Chicken Pasta Bake beautifully.

One Pan, More Ideas

• Try the Tuscan Garlic Chicken Pasta for another creamy, flavorful chicken pasta dish.
• If you love sun-dried tomatoes, the Creamy Sun Dried Tomato Chicken Penne is a must-try.
• For a rich and indulgent meal, the Creamy Marry Me Chicken Pasta is a fantastic option.

Next Steps

Once you’ve mastered this Creamy Tuscan Chicken Pasta Bake, experiment with swapping in different cheeses or adding your favorite vegetables to make it your own. Try making a double batch and freezing portions for quick dinners on busy nights. Don’t forget to share this recipe with friends and family—they’ll thank you for introducing them to this comforting classic.

Ready to dive into this creamy, cheesy, and utterly satisfying pasta bake? Gather your ingredients and start cooking—you’re about to enjoy one of the most delicious meals you’ll make all week!

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