Shrimp Cajun Macaroni Bake

There’s something incredibly comforting about a baked pasta dish that combines creamy cheese, bold spices, and succulent shrimp. This Shrimp Cajun Macaroni Bake is the perfect marriage of Southern flavor and cheesy goodness, making it an irresistible option for weeknight dinners or casual gatherings. With tender elbow macaroni swimming in a creamy, spicy tomato sauce, topped with melted cheddar and mozzarella, every bite is a celebration of flavor and texture. Whether you’re a seafood lover or just looking to spice up your pasta routine, this dish is sure to become a favorite.

Why It’s Crowd-Pleasing

This Shrimp Cajun Macaroni Bake hits all the right notes for a crowd-pleasing meal. First, the Cajun seasoning delivers a smoky, slightly spicy kick that wakes up your taste buds without overwhelming them. The shrimp add a delightful seafood sweetness and a tender bite, while the combination of cheddar and mozzarella cheeses ensures a rich, gooey texture that everyone loves. The inclusion of diced tomatoes with green chilies adds just the right amount of acidity and a subtle heat, balancing the creamy sauce perfectly. Plus, it’s baked to golden perfection, creating a delightful crust that contrasts beautifully with the soft macaroni inside.

This dish also offers versatility—serve it as a hearty main course or pair it with a crisp green salad or steamed veggies for a complete meal. Its vibrant flavors and comforting texture make it an excellent choice for family dinners, potlucks, or meal prep for busy weeks ahead.

Ingredients at a Glance

• 8 ounces elbow macaroni
• 1 pound large shrimp, peeled and deveined
• 1 tablespoon olive oil
• 1 small onion, diced
• 1 green bell pepper, diced
• 2 cloves garlic, minced
• 1 tablespoon Cajun seasoning
• 1 can (10 ounces) diced tomatoes with green chilies
• 1 cup heavy cream
• 1 cup shredded cheddar cheese
• 1 cup shredded mozzarella cheese
• Salt and pepper to taste
• 2 green onions, chopped for garnish

Essential Tools for Success

• Large pot – for boiling the macaroni
• Large skillet – to sauté the shrimp and vegetables
• Baking dish (about 9×9 inches) – for assembling and baking the macaroni
• Mixing spoon or spatula – for stirring ingredients
• Cheese grater – if shredding your own cheese
• Colander – to drain cooked pasta

Mastering Shrimp Cajun Macaroni Bake: How-To

Step 1: Cook the elbow macaroni

Bring a large pot of salted water to a boil. Add the elbow macaroni and cook according to package instructions until al dente—usually about 7 to 8 minutes. Drain and set aside.

Step 2: Sauté the shrimp and vegetables

Heat the olive oil in a large skillet over medium heat. Add the diced onion and green bell pepper, cooking until softened, about 3 to 4 minutes. Stir in the minced garlic and cook for another minute until fragrant.

Add the peeled and deveined shrimp along with the Cajun seasoning. Cook until the shrimp turn pink and opaque, about 3 to 5 minutes. Remove from heat.

Step 3: Create the creamy Cajun sauce

To the skillet with shrimp and veggies, add the can of diced tomatoes with green chilies (including the juice) and the heavy cream. Stir everything together and bring to a gentle simmer. Let it cook for 2 to 3 minutes to meld the flavors.

Step 4: Combine pasta and sauce

Add the cooked macaroni to the skillet, stirring to coat every piece in the rich, spicy sauce. Season with salt and pepper to taste. Remove from heat once everything is well combined.

Step 5: Assemble and bake

Preheat your oven to 375°F (190°C). Transfer the macaroni and shrimp mixture to your baking dish. Sprinkle the shredded cheddar and mozzarella cheeses evenly over the top.

Bake uncovered for 20 to 25 minutes, or until the cheese is melted, bubbly, and golden brown on the edges.

Step 6: Garnish and serve

Remove from the oven and let it cool slightly before garnishing with freshly chopped green onions. Serve warm and enjoy this hearty, flavorful dish!

If you love this recipe, you might also want to check out my Creamy Cajun Shrimp Pasta Bake for another twist on Cajun-inspired seafood pasta.

Vegan & Vegetarian Swaps

• Shrimp: Substitute with seasoned and sautéed mushrooms or vegan shrimp alternatives.
• Heavy Cream: Use full-fat coconut milk or cashew cream for a creamy texture.
• Cheddar and Mozzarella Cheese: Replace with plant-based shredded cheeses.
• Cajun Seasoning: Ensure it’s free of animal-derived ingredients or make your own blend with smoked paprika, cayenne, garlic powder, and dried herbs.

Pro Tips & Notes

• Don’t overcook the shrimp in the skillet; they will continue cooking in the oven and can become rubbery.
• For a bit of extra crunch, sprinkle some panko breadcrumbs mixed with a little melted butter on top before baking.
• If you prefer a spicier dish, add more Cajun seasoning or a pinch of cayenne pepper.
• Use freshly shredded cheese instead of pre-shredded for better melting and flavor.
• Make sure to drain the macaroni well to avoid a watery bake.

Storage Pro Tips

This Shrimp Cajun Macaroni Bake stores beautifully for up to 3 days in an airtight container in the refrigerator. To reheat, cover with foil and warm in a 350°F (175°C) oven until heated through, or microwave in short bursts, stirring occasionally.

For longer storage, freeze the baked dish before adding the cheese topping. When ready to enjoy, thaw overnight and add cheese before baking as directed.

Frequently Asked Questions

Can I use frozen shrimp for this recipe?

Yes, you can use frozen shrimp—just be sure to thaw them completely and pat dry before cooking to avoid excess moisture in the dish.

What type of Cajun seasoning works best?

A balanced Cajun seasoning with paprika, garlic powder, onion powder, cayenne, oregano, and thyme works perfectly. Adjust the amount based on your preferred spice level.

Can I make this recipe ahead of time?

Absolutely! Prepare the casserole up to the baking step, cover it, and refrigerate for up to 24 hours before baking. This makes it great for meal prep or entertaining.

Is it possible to make this recipe dairy-free?

Yes! Swap the heavy cream with coconut or cashew cream, and use dairy-free cheeses to keep the creamy texture and flavor while accommodating dietary needs.

More Recipes You’ll Love

• Good Ole Mac And Cheese – a classic comfort food staple.
• Creamy Cajun Shrimp Pasta Bake – another delicious twist on Cajun-spiced seafood pasta.

Hungry for More?

If you’re craving more delicious, easy-to-make dishes that bring bold flavors and comfort to your table, be sure to explore other recipes that celebrate vibrant spices and cheesy goodness. Whether it’s a quick pasta bake or a slow-cooked stew, these meals are designed to satisfy and impress with minimal fuss.

This Shrimp Cajun Macaroni Bake is an excellent example of how simple ingredients can come together to create a dish bursting with flavor and texture. Perfect for weeknight dinners or feeding a hungry crowd, it’s sure to become a staple in your recipe rotation. For those who appreciate the creamy, cheesy goodness of macaroni dishes, this recipe offers an exciting Cajun twist that elevates every bite. So gather your ingredients, preheat your oven, and get ready to enjoy a hearty meal that’s as comforting as it is flavorful!

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