Rinse the boneless, skinless chicken thighs under cold water and pat them dry with paper towels.
In a large bowl, combine the Italian seasoning, onion powder, garlic powder, kosher salt, and ground black pepper. Sprinkle this mixture evenly over the chicken thighs.
Turn on the Instant Pot and select the 'Sauté' function. Once hot, add a splash of oil and place the seasoned chicken thighs in the pot. Sear for about 4-5 minutes on each side until golden brown.
Once browned, carefully pour in the low-sodium chicken broth and scrape the bottom of the pot with a wooden spoon.
Close the lid of the Instant Pot and set the valve to 'Sealing.' Select 'Manual' or 'Pressure Cook' and set the timer for 10 minutes.
When the cooking time is up, allow the Instant Pot to naturally release pressure for 5 minutes, then switch the valve to 'Venting' to release remaining pressure.
Remove the chicken thighs from the pot and serve with the remaining broth as a sauce.