Preheat the oven to 400°F (200°C).
Arrange the 4 tilapia fillets in a single layer in an ovenproof baking dish. Pat fillets dry with paper towels if desired.
Season both sides of the fillets with salt and pepper.
Zest one lemon and then squeeze its juice into a small bowl. Thinly slice the other lemon into rounds.
Melt 4 tablespoons butter in a small saucepan over low heat or in a microwave-safe bowl in short bursts until fully melted.
Stir the melted butter together with 3 minced garlic cloves, 3 tablespoons chopped parsley, 1/4 teaspoon red pepper flakes, and the lemon zest and juice until combined.
Pour the lemon-butter mixture evenly over the tilapia fillets. Use a brush or spoon to make sure the fish is fully coated.
Arrange the lemon slices on top of the fillets.
Bake in the preheated oven for 10 minutes.
After baking, switch the oven to broil and broil the fish for 2 minutes, watching closely to avoid burning, until the fish easily flakes with a fork. Remove and serve.