Prepare the pasta according to package directions, drain, and set aside.
Heat 2 teaspoons olive oil in a large, deep skillet or soup pot over medium-high heat.
Add 1/2 cup finely chopped yellow onion and 1/4 cup each finely chopped red and green bell pepper; sauté until the vegetables are softened, about 3–4 minutes.
Add 3 minced garlic cloves and cook, stirring, until fragrant, about 30–60 seconds (take care not to burn the garlic).
Add 1 cup chicken andouille sausage (or regular andouille), cut into 1" cubes, and sauté until heated through and lightly browned, about 4–5 minutes, stirring occasionally.
Stir in 1 Tablespoon Cajun seasoning and 2 cups shredded cooked chicken; cook, stirring, until the shredded chicken is heated through, about 2–3 minutes.
Add the cooked penne and stir to combine.
Slowly pour in 1 1/2 cups skim milk while stirring, bring the mixture to a gentle simmer, and cook uncovered for about 5 minutes.
In a small bowl, whisk 1 Tablespoon cornstarch (or arrowroot or tapioca starch) with 1/4 cup chicken broth until completely smooth. Pour this slurry into the simmering pot while stirring constantly and continue to simmer until the sauce thickens, about 1–2 minutes.
Remove from heat, add 1/2 cup shredded lowfat Parmesan cheese, and stir until the cheese melts and the sauce is smooth. Serve immediately.